Rituximab renal dosing handbook

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The combination of cisplatin and rituximab is not an approved treatment regimen. Monitor closely for signs of renal failure and discontinue rituximab in patients with a rising serum creatinine or oliguria. No formal studies have been conducted to examine the effects of renal impairment on the pharmacokinetics of rituximab.
received at least one full dose of a rituximab product by intravenous infusion. (1.4, 2.1, 5.4). Renal toxicity: Discontinue in patients with rising serum creatinine or Refer to the prescribing information for a rituximab product for intravenous infusion for additional information.
Next, what is the optimal dose of rituximab, and should dosing be targeted at B cell response? Most studies in this review used the protocol suggested in the first publication of Remuzzi et al. ( 10 ) of 375 mg/m 2 rituximab, once weekly for 4 wk, in MN, which was derived from the standard regimen used in treating lymphoma ( 37 , 38 ).
Learn more about dosing and administrating Rituxan® (rituximab) for GPA & MPA including before, during, and after treatment guidelines. See full safety for more information.
Following a single dose of rituximab, only 24% had established (>18 weeks) BCD. In those patients with SLE that depleted, the median time to repopulation was 150 days (5 months), and 9 months after dosing the probability of persistent BCD was 19% (s. e. m. 10%). Therefore the single-dose rituximab strategy was abandoned for treatment of active SLE.
Learn about the established RITUXAN® (rituximab) dosing regimens for non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia. See full safety for more information. See full safety for more information.
Closer monitoring rather than substantially lower doses may be appropriate in severe renal impairment if patients have life-threatening disease. Prednisolone. Corticosteroids are a vital part of therapy, but the cumulative dose of steroids is also a major determinant of the risk of infection.
1,400 mg rituximab and 23,400 units hyaluronidase (11.7 mL) subcutaneously into the abdomen over about 5 minutes on day 1 in combination with chemotherapy repeated every 21 days on cycles 2 to 8 following a full dose of an IV infusion rituximab product on day 1 of cycle 1 for a total of 8 rituximab doses. The Drugs which are in bold, details of dose reductions are mentioned below table, scroll down. GuideLines for Chemotherapy Dosage Adjustment Adjust if Function Impaired Hepatic Renal Alemtuzumab No No Arsenic trioxide Yes Yes Asparaginase (E coli) +/- +/- Asparaginase Read More ›
This article reviews the current use of rituximab in renal disease and transplantation, and includes discussion of the drug’s potential role in novel therapeutic protocols. a phase I/II dose
Finally, a single case of an initial increase in cryoglobulin level (1 day after the first rituximab dose) The specific effect of rituximab on renal lupus What to Read Next on Medscape.

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